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RESEARCH LIBRARY RECORD

Single-Cell Transcriptomics Uncover Key Regulators of Skin Regeneration in Human Long-Term Mechanical Stretch-Mediated Expansion Therapy

Supports biological plausibility or background only. It does not validate a foreskin-restoration device, method, force, duration, or timeline.

Mechanistic evidenceHuman anatomy or histology

By Foreskin Online Editorial Published August 11, 2026 Updated August 11, 2026 Educational information

Source details

Authors
Yidan Sun et al.
Journal or source
Frontiers in Cell and Developmental Biology
Year
2022
DOI or authoritative URL
10.3389/fcell.2022.865983
Study type
Human single-cell transcriptomic study
Population or material studied
Human skin samples from clinical long-term mechanical expansion therapy.
Major findings
Characterized cell populations and candidate regulatory programs associated with human mechanically expanded skin.
Limitations
Clinical reconstructive tissue and molecular associations do not establish restoration outcomes or a usable tension prescription.
Relevance to restoration
Supports biological plausibility or background only. It does not validate a foreskin-restoration device, method, force, duration, or timeline.
Source-review status
Abstract reviewed
Last reviewed
2026-08-11

Characterized cell populations and candidate regulatory programs associated with human mechanically expanded skin.

Read the limitations

This record is an editorial summary. Follow the DOI or authoritative source, consider the study design and population, and do not generalize beyond what was studied.