Source details
- Authors
- Mariaceleste Aragona et al.
- Journal or source
- Nature
- Year
- 2020
- DOI or authoritative URL
- 10.1038/s41586-020-2555-7
- Study type
- Animal experimental single-cell study
- Population or material studied
- Mouse skin subjected to controlled mechanical stretch.
- Major findings
- Identified spatial and cell-state responses during stretch-mediated skin expansion, including epidermal and dermal programs.
- Limitations
- Animal model with controlled experimental loading; anatomy, loading, and timescale differ from restoration. A 2025 author correction amended duplicated image panels and stated that conclusions were unaffected.
- Relevance to restoration
- Supports biological plausibility or background only. It does not validate a foreskin-restoration device, method, force, duration, or timeline.
- Source-review status
- Full text reviewed
- Last reviewed
- 2026-08-11
- Correction or related DOI
- 10.1038/s41586-025-09878-z
Identified spatial and cell-state responses during stretch-mediated skin expansion, including epidermal and dermal programs.
Read the limitations
This record is an editorial summary. Follow the DOI or authoritative source, consider the study design and population, and do not generalize beyond what was studied.