Source details
- Authors
- Yaotao Guo; Yajuan Song; Shaoheng Xiong; Tong Wang; Wei Liu; Zhou Yu; Xianjie Ma
- Journal or source
- International Journal of Molecular Sciences
- Year
- 2022
- DOI or authoritative URL
- 10.3390/ijms23179622
- Study type
- Narrative mechanistic review
- Population or material studied
- Cell, animal, and clinical literature concerning reconstructive skin soft-tissue expansion.
- Major findings
- Reviews cellular proliferation, extracellular-matrix remodeling, angiogenesis, and mechanotransduction during expansion.
- Limitations
- A broad secondary review with mixed evidence types; terminology such as regeneration refers to tissue expansion biology, not recreation of a removed foreskin.
- Relevance to restoration
- Supports biological plausibility or background only. It does not validate a foreskin-restoration device, method, force, duration, or timeline.
- Source-review status
- Abstract reviewed
- Last reviewed
- 2026-08-11
Reviews cellular proliferation, extracellular-matrix remodeling, angiogenesis, and mechanotransduction during expansion.
Read the limitations
This record is an editorial summary. Follow the DOI or authoritative source, consider the study design and population, and do not generalize beyond what was studied.